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kkoenen@hsph.harvard.edu

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cnievergelt@ucsd.edu

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kressler@mclean.harvard.edu

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Dalvie, S., Chatzinakos, C., Al Zoubi, O., Georgiadis, F., PGC-PTSD Systems Biology workgroup, Lancashire, L., Daskalakis, N.P. From genetics to systems biology of stress-related mental disorders. Neurobiology of Stress (2021)

https://pgc-ptsd.com/wp-content/uploads/2021/09/SysBioPTSD_2021.pdf

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Garrett, M.E., Qin, X.J., Divya, M., … Beckham, J.C., Hauser, M.A., Ashley-Koch, A.E. Gene expression analysis in three posttraumatic stress disorder cohorts implicates inflammation and innate immunity pathways and uncovers shared genetic risk with major depressive disorder. Frontiers in Neuroscience (2021)

https://pgc-ptsd.com/wp-content/uploads/2021/07/PGC-PTSD_GEx_Manuscript_resubmission_jul21.pdf

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Sumner, J.A., Maihofer, A.X., Michopoulos, V., … Zoellner, L.A., Nievergelt, C.M., Wolf, E.J. Examining Individual and Synergistic Contributions of PTSD and Genetics to Blood Pressure: A Trans-Ethnic Meta-Analysis. Fronteirs in Neuroscience (2021), https://doi.org/10.3389/fnins.2021.678503

https://www.frontiersin.org/articles/10.3389/fnins.2021.678503/full

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Logue M.W., Miller M.W., Wolf E.J., … Milberg W.P., Hayes J.P., Verfaellie M. An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci. Clinical Epigenetics (2020)

https://pgc-ptsd.com/wp-content/uploads/2021/09/epigenome-wide-association-study-of-PTSD-in-us-veterans.pdf

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https://pgc-ptsd.com/wp-content/uploads/2021/09/epigenome-wide-association-study-of-PTSD-in-us-veterans.pdf

Snijders C., Maihofer A.X., Ratanatharathorn A., … Uddin M., Rutten B.P.F., Nievergelt C.M. Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorderClinical Epigenetics (2020)

https://pgc-ptsd.com/wp-content/uploads/2021/09/longitudinal-epigenome-wide-association-studies-of-three-male-military-cohorts-.pdf

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Smith A.K., Ratanatharathorn A., Maihofer A.X., … Uddin M., Nievergelt C.M. Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies novel methylation loci. Nature Communications (2020)

https://pgc-ptsd.com/wp-content/uploads/2021/09/Epigenome-wide-meta-analysis-of-PTSD.pdf

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Wang, X., Xie, H., Chen, T., … Thompson, P.M., Morey, R.A., Liberzon, I. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis. Molecular Psychiatry (2020), doi:10.1038/s41380-020-00967-1

https://www.nature.com/articles/s41380-020-00967-1

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Huckins, L.M., Chatzinakos, C., Breen, M.S., … Ressler, K.J, Stahl, E.A., Daskalakis, N.P. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Reports (2020), doi:10.1016/j.celrep.2020.107716

https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30693-8

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Vinkers C., Geuze E., van Rooij S., ... Rutten B, Vermetten E, Boks M. Successful treatment of Post-Traumatic Stress Disorder reverses DNA methylation marks. Molecular Psychiatry (2019) doi: 10.1038/s41380-019-0549-3. PMID: 31645664.

https://pgc-ptsd.com/wp-content/uploads/2021/09/successful-treatment-of-post-traumatic-stress-disorder-reverses-DNA-methylation-marks.pdf

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Dennis, E.L., Disner, S.G., Fani, N. et al. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium. Mol Psychiatry (2019) doi:10.1038/s41380-019-0631-x

https://www.nature.com/articles/s41380-019-0631-x

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Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C.-Y., Choi, K. W., . . . Koenen, K. C. (2019). International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications, 10(1), 4558. doi: 10.1038/s41467-019-12576-w

https://www.nature.com/articles/s41467-019-12576-w

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Wolf E.J., Maniates H., Nugent N., … Smith A.K., Nievergelt C.M., Logue M.W. Traumatic stress and accelerated DNA methylation age: A meta-analysisPsychoneuroendocrinology (2018). PMCID: PMC5924645.

https://pgc-ptsd.com/wp-content/uploads/2021/09/Traumatic-stress-and-accelerated-DNA-.pdf

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Nievergelt, C. M., Ashley-Koch, A. E., Dalvie, S., Hauser, M. A., Morey, R. A., Smith, A. K., & Uddin, M. (2018). Genomic approaches to posttraumatic stress disorder: The Psychiatric Genomic Consortium initiative. Biological psychiatry (2018), https://doi.org/10.1016/j.biopsych.2018.01.020

https://www.sciencedirect.com/science/article/pii/S0006322318300684#fig2

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Uddin M., Ratanatharathorn A., Armstrong D., … Wildman D.E., Nievergelt C.M., Smith A. Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder: Epigenomics (2018), PMCID: PMC6331697.

https://pgc-ptsd.com/wp-content/uploads/2021/09/Epigenetic-meta-analysis-across-three-civilian.pdf

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Ratanatharathorn A., Boks M.P., Maihofer A.X., , … Uddin M., Nievergelt C.M., Smith A.K. Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline. Am J Med Genet B Neuropsychiatr Genet (2017)

https://pgc-ptsd.com/wp-content/uploads/2021/09/epigenome-wide-association-study-of-PTSD-in-us-veterans.pdf

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J . A . Sumner, L . E . Duncan  , E . J. Wolf , A . B . Amstadter, D . G . Baker, J . C . Beckham, B . Gelaye , S . Hemmings , N . A . Kimbrel , M . W. Logue , V. Michopoulos , K . S . Mitchell , C . Nievergelt, A . Rothbaum, S . Seedat , G . Shinozaki , and E . Vermetten. Posttraumatic stress disorder has genetic overlap with cardiometabolic traitsPsychological Medicine (2017), doi: 10.1017/S0033291717000733

https://pgc-ptsd.com/wp-content/uploads/2017/11/Sumner-et-al.-2017-PGC-PTSD-Physical-Health.pdf

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Mark W. Logue, Sanne J.H. van Rooij∗, Emily L. Dennis∗, Sarah L. Davis, Jasmeet P. Hayes, Jennifer S. Stevens, Maria Densmore, Courtney C. Haswell, Jonathan Ipser, Saskia B. Koch, Mayuresh Korgaonkar, Lauren A.M. Lebois, Matthew Peverill, Justin T. Baker, Premika S.W. Boedhoe, Jessie L. Frijling, Staci A. Gruber, Ilan Harpaz-Rotem, Neda Jahanshad, Sheri Koopowitz, Ifat Levy, Laura Nawijn, Lauren O’Connor, Miranda Olff, David H. Salat, Margaret A. Sheridan, Jeffrey M. Spielberg, Mirjam van Zuiden, Sherry R. Winternitz, Jonathan D. Wolff, Erika J. Wolf, Xin Wang, Kristen Wrocklage, Chadi G. Abdallah, Richard A. Bryant, Elbert Geuze, Tanja Jovanovic, Milissa L. Kaufman, Anthony P. King, John H. Krystal, Jim Lagopoulos, Ruth Lanius, Israel Liberzon, Regina E. McGlinchey, Katie A. McLaughlin, William P. Milberg, Mark W. Miller, Kerry J. Ressler, Dick J. Veltman, Dan J. Stein, Kathleen Thomaes, Paul M. Thompson, Rajendra A. Morey. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multi-Site ENIGMA-PGC Study. Biological Psychiatry (2017), doi: 10.1016/j.biopsych.2017.09.006.

http://www.biologicalpsychiatryjournal.com/article/S0006-3223(17)31990-X/fulltext

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Andrew Ratanatharathorn, Marco P. Boks, Adam X. Maihofer, Allison E. Aiello, Ananda B. Amstadter, Allison E. Ashley-Koch, Dewleen G. Baker, Jean C. Beckham, Evelyn Bromet, Michelle Dennis, Melanie E. Garrett, Elbert Geuze, Guia Guffanti, Michael A. Hauser, Varun Kilaru, Nathan A. Kimbrel, Karestan C. Koenen, Pei-Fen Kuan, Mark W. Logue, Benjamin J. Luft, Mark W. Miller, Colter Mitchell, Nicole R. Nugent, Kerry J. Ressler, Bart P. F. Rutten, Murray B. Stein, Eric Vermetten, Christiaan H. Vinkers, Nagy A. Youssef, VA Mid-Atlantic MIRECC Workgroup, PGC PTSD Epigenetics Workgroup, Monica Uddin, Caroline M. Nievergelt, Alicia K. Smith. Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline. Am J Med Genet. 174B:619–630. 2017

https://www.ncbi.nlm.nih.gov/pubmed/28691784

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Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen C-Y, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC. Largest GWAS of PTSD (N=20,070) Yields Genetic Overlap with Schizophrenia and Sex Differences in Heritability. Molecular Psychiatry. 00, pp 1-8. 2017

http://www.nature.com/mp/journal/vaop/ncurrent/full/mp201777a.html

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Logue MW, Amstadter AB, Baker DG, Duncan L, Koenen KC, Liberzon I, Miller MW, Morey RA, Nievergelt CM, Ressler KJ, Smith AK, Smoller JW, Stein  MB, Sumner JA, Uddin M.  The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic stress disorder enters the age of large-scale genomic collaboration. Neuropsychopharmacology. 2015; 40(10):2287-97.

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