A. Research Question, Goal, or Specific Aims Traumatic experiences cause acute posttraumatic stress symptoms (PTSS) in survivors, which can be exacerbated by comorbidly incurred mild to moderate traumatic brain injury …
Read Toledo’s Acute Trauma Proposal
Read King’s College London’s Proposal
A. Research Question, Goal, or Specific Aims Where in the brain (on a voxel-by-voxel basis) is the gray and white matter volume different in patients with PTSD compared to a …
structural ProposalsRead Duke’s Cerebellar Volume Proposal
Cerebellar volume based structural alterations in PTSD I. Title: Cerebellar volume based structural alterations in PTSD II. Investigative Team: Ashley Huggins Melvin Briggs Delin Sun Sarah Laskowitz C. Lexi Baird …
Read Liat Helpman’s proposal
Identifying Sex-Dependent Connectivity patterns in Trauma and PTSD A. Research Question, Goal, or Specific Aims Aim 1: We plan to replicate our findings (Helpman et al., 2021) regarding sex-dependent functional …
Read Lauren Salminen’s abstract
PTSD and depression show unique trauma-related signatures in the hippocampal subfields: International analysis from the PGC-ENIGMA PTSD Working Group Lauren E. Salminen, Mark W. Logue, Yuanchao Zheng, Philipp Saemann, Emily …
structural ProposalsRead the cortical analysis proposal by Duke University:
We propose to apply the structural covariance network analyses to obtain centrality measures using subjects from PGC-PTSD neuroimaging dataset.
structural ProposalsRead the Analysis Proposal from Duke:
Using data from the PTSD Psychiatric Genetics Consortium (PGC-PTSD) neuroimaging project, we will extract thalamic volumes from subjects across 29 different sites. We have two groups of subjects – controls (trauma exposed or healthy) and subjects with PTSD. Possible covariates for the data include age, gender, childhood trauma score, alcohol use and comorbid MDD.
structural ProposalsRead the Analysis Proposal from Duke:
We specifically hypothesized that
the structural covariance between regions with cortical thickness reduction in PTSD patients
would be stronger compared with the structural covariance between randomly selected regions
in both PTSD and controls, would be stronger in patients with PTSD than in controls, would be
stronger in PTSD patients with more severe symptoms, and would be modulated by factors
such as age and gender.
structural ProposalsRead the Brain Age Analysis Proposal
the goal of the proposed project will be to identify peripheral
epigenomic predictors of brain aging from cross-sectional data in PTSD. This goal will be pursued
along two aims: 1) identify composite DNA methylation-based markers and/or distinct DNA
methylation sites in either blood or saliva that may be associated with accelerated structural MRIpredicted
brain aging and/or its rate of change; and 2) test whether PTSD/control case status and/or
other parameters (such as sex, lifestyle factors, and blood cell composition) moderate these
associations.
structural ProposalsRead the harmonization proposal from Duke:
In the present study, we aim to compare results from three different harmonization approaches (1) LME, (2) ComBat, and (3) ComBat-GAM. We propose comparing methods using cortical thickness data from 29 ENIGMA-PTSD sites as a test case to investigate age-related trajectories of cortical thickness in participants with PTSD.