Systems Biology Workgroup

///Systems Biology Workgroup
Systems Biology Workgroup 2018-07-31T13:17:19+00:00

Group Leaders: Dr. Nikolaos Daskalakis, M.D. Ph.D. and Dr. Shareefa Dalvie, Ph.D.

Reductionist unimodal techniques did not have substantial success in identifying causal mechanisms for PTSD. There is a need for a more integrated multimodal approach to study the complex interplay between biological and phenotypic constructs.

We aim to delineate complex processes underlying PTSD using a systems biology approach by integrating biological and phenotypic “layers”.

Dr. Nikolaos Daskalakis, MD, PhD

Dr. Daskalakis, MD, PhD, is an associate neuroscientist at McLean Hospital and member of the faculty of Psychiatry at Harvard Medical School. He is also director of Data-science and Translational-medicine. He has received several young investigator awards including the 2015 BBRF-NARSAD Young Investigator and 2018 Brooking Mental Health Research Scholar. He received his MD from University of Athens, his PhD in neuropsychopharmacology from Leiden University, and completed post-doctoral fellowships in clinical neuroendocrinology at Leiden University Medical Center and in molecular psychiatry/bioinformatics at Icahn School of Medicine.

Dr.Daskalakis’ research focuses on the interaction between stress and the brain in health and disease, conducting translational studies in humans and animals following an integrative systems approach. He uses whole tissue and cell type specific RNA sequencing and epigenetic profiling, from the brain, induced neuronal cells, and blood, to identify gene pathways and networks associated with vulnerability and resilience to PTSD. As a member of the Psychiatric Genomic Consortium PTSD Workgroup, Dr. Daskalakis leads large-scale genetic-based analyses and the Systems Biology working group.

Dr. Shareefa Dalvie, PhD

Dr. Dalvie, PhD, is a faculty member at the Department of Psychiatry & Mental Health at the University of Cape Town (UCT) in South Africa and co-heads the Psychiatric Neurogenetics group of the Brain-Behaviour Unit (BBU) at UCT. She completed her doctoral degree at the Division of Human Genetics at UCT and held a Brain-Behaviour Initiative (BBI) postdoctoral fellowship from the Department of Psychiatry & Mental Health. Dr Dalvie’s research interests include the genetic basis of trauma exposure in individuals with post-traumatic stress disorder (PTSD), network analysis for PTSD integrating “omic” layers, and gene-imaging analysis. Dr Dalvie is also a visiting scholar at the University of California, San Diego (UCSD) in the USA and co-leads the Systems Biology working group of the Psychiatric Genomics Consortium (PGC)-PTSD. She is also a Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER) research fellow (Stanley Center for Psychiatric Research and Harvard T. H. Chan School of Public Health, USA).