Diagnosis and Trauma Exposure Harmonization Core
The harmonization of measures of trauma exposure across studies is an additional complication for PTSD genetics research. Though the DSM offers a broad definition of the types of events known to cause PTSD, there is no uniform or generally agreed-upon framework for categorizing or measuring them. A variety of self-report measures of trauma exposure are represented among PGC–PTSD studies. Most consist of a list of events that meet the DSM-IV PTSD Criterion A1 trauma definition including exposure to sexual or physical assault, combat or warfare, sudden death of friend/loved one, and so on. Most also make it possible to re-classify events for harmonization purposes into broader categories such as childhood vs adult trauma, or interpersonal versus non-interpersonal trauma, or to compute a measure of total trauma load.