Uddin M., Ratanatharathorn A., Armstrong D., … Wildman D.E., Nievergelt C.M., Smith A. Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder: Epigenomics (2018), PMCID: PMC6331697.
Aim: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD.
Materials & methods: We conducted a meta-analysis of PTSD epigenome-wide association studies
in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels
were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD
working group of the Psychiatric Genomics Consortium.
Results: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098). Conclusion: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.
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